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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Ed Walsh* | 1.816 | 1904-1917 | |
| 2 | Addie Joss | 1.887 | 1902-1910 | |
| 3 | Mordecai Brown* | 1.928 | 1903-1916 | |
| 4 | Jack Pfiester | 2.024 | 1903-1911 | |
| 5 | Smoky Joe Wood | 2.030 | 1908-1920 | |
| 6 | Jim A Devlin | 2.050 | 1875-1877 | |
| 7 | Monte Ward* | 2.102 | 1878-1894 | |
| 8 | Christy Mathewson* | 2.133 | 1900-1916 | |
| 9 | Al Spalding* | 2.136 | 1871-1877 | |
| 10 | Rube Waddell* | 2.161 | 1897-1910 | |
| 11 | Walter Johnson* | 2.167 | 1907-1927 | |
| 12 | Jake Weimer | 2.231 | 1903-1909 | |
| 13 | Orval Overall | 2.233 | 1905-1913 | |
| 14 | Will White | 2.276 | 1877-1886 | |
| 15 | Babe Ruth* | 2.277 | 1914-1935 | |
| 16 | Ed Reulbach | 2.290 | 1905-1917 | |
| 17 | Jim Scott | 2.298 | 1909-1917 | |
| 18 | Tommy Bond | 2.312 | 1874-1884 | |
| 19 | Reb Russell | 2.334 | 1913-1919 | |
| 20 | Andy Coakley | 2.350 | 1902-1911 | |
| 21 | Larry Corcoran | 2.355 | 1880-1887 | |
| 22 | Charles Bender* | 2.359 | 1903-1925 | |
| 23 | Eddie Plank* | 2.367 | 1901-1917 | |
| 24 | George McQuillan | 2.381 | 1907-1918 | |
| 25 | Eddie Cicotte | 2.382 | 1905-1920 | |
| 25 | Ed Killian | 2.382 | 1903-1910 | |
| 27 | Doc White | 2.391 | 1901-1913 | |
| 28 | Harry Coveleski | 2.394 | 1907-1918 | |
| 29 | Carl Lundgren | 2.417 | 1902-1909 | |
| 30 | George Bradley | 2.418 | 1875-1884 | |
| 31 | Nap Rucker | 2.421 | 1907-1916 | |
| 32 | Jeff Tesreau | 2.428 | 1912-1918 | |
| 33 | Joe Benz | 2.429 | 1911-1919 | |
| 34 | Jim McCormick | 2.431 | 1878-1887 | |
| 35 | Terry Larkin | 2.435 | 1876-1880 | |
| 36 | Frank E Smith | 2.446 | 1904-1912 | |
| 37 | Sam Leever | 2.473 | 1898-1910 | |
| 37 | Lefty Leifield | 2.473 | 1905-1920 | |
| 39 | Hooks Wiltse | 2.477 | 1904-1914 | |
| 40 | Hippo Vaughn | 2.486 | 1908-1921 | |
| 41 | Candy Cummings* | 2.491 | 1872-1877 | |
| 42 | Bob Ewing | 2.492 | 1902-1912 | |
| 43 | Cy Morgan | 2.509 | 1903-1913 | |
| 44 | Ray Collins | 2.513 | 1909-1915 | |
| 45 | Lew Richie | 2.536 | 1906-1913 | |
| 46 | Russ Ford | 2.540 | 1909-1913 | |
| 47 | Noodles Hahn | 2.546 | 1899-1906 | |
| 48 | Frank Owen | 2.552 | 1901-1909 | |
| 49 | Rudy May | 2.553 | 1965-1976 | |
| 50 | Pete Alexander* | 2.560 | 1911-1930 | |
| 50 | Burt Hooton | 2.560 | 1971-1978 | |
| 52 | Slim Sallee | 2.564 | 1908-1921 | |
| 53 | Ron Perranoski | 2.566 | 1961-1975 | |
| 54 | Tom Seaver | 2.586 | 1967-1979 | |
| 54 | Deacon Phillippe | 2.586 | 1899-1911 | |
| 56 | Ed Siever | 2.598 | 1901-1908 | |
| 56 | Sam McDowell | 2.598 | 1961-1979 | |
| 58 | Bob Rhoads | 2.612 | 1902-1909 | |
| 59 | Fred Glade | 2.618 | 1902-1908 | |
| 60 | Gary Nolan# | 2.619 | 1967-1981 | |
| 61 | Tim Keefe* | 2.625 | 1880-1893 | |
| 62 | Cy Young* | 2.627 | 1890-1911 | |
| 63 | Vic Willis | 2.628 | 1898-1910 | |
| 64 | Red Ames | 2.629 | 1903-1919 | |
| 65 | Barney Pelty | 2.632 | 1903-1912 | |
| 66 | Nick Altrock | 2.645 | 1898-1924 | |
| 67 | Joe McGinnity* | 2.657 | 1899-1908 | |
| 67 | Dick Rudolph | 2.657 | 1910-1927 | |
| 69 | Howie Camnitz | 2.660 | 1904-1913 | |
| 69 | Earl Moore | 2.660 | 1901-1913 | |
| 71 | Juan Marichal | 2.661 | 1960-1974 | |
| 72 | Jack W Taylor | 2.662 | 1898-1907 | |
| 73 | Pete Schneider | 2.663 | 1914-1919 | |
| 74 | Carl Weilman | 2.669 | 1912-1920 | |
| 75 | Charlie J Ferguson | 2.674 | 1884-1887 | |
| 76 | Old Hoss Radbourn* | 2.675 | 1881-1891 | |
| 77 | Johnny Lush | 2.680 | 1904-1910 | |
| 78 | Jack Chesbro* | 2.684 | 1899-1909 | |
| 79 | Fred Toney | 2.689 | 1911-1923 | |
| 80 | Bill Donovan | 2.690 | 1898-1918 | |
| 81 | Larry Cheney | 2.698 | 1911-1919 | |
| 82 | Vean Gregg | 2.701 | 1911-1925 | |
| 83 | Mickey Welch | 2.712 | 1880-1892 | |
| 84 | Ned Garvin | 2.718 | 1896-1904 | |
| 85 | Bob Wicker | 2.726 | 1901-1906 | |
| 86 | Fred Goldsmith | 2.729 | 1879-1884 | |
| 87 | Harry Howell | 2.738 | 1898-1910 | |
| 88 | Whitey Ford* | 2.745 | 1950-1967 | |
| 89 | Dummy Taylor | 2.747 | 1900-1908 | |
| 90 | Roy Patterson | 2.749 | 1901-1907 | |
| 91 | Babe Adams | 2.755 | 1906-1926 | |
| 92 | Ron Guidry# | 2.757 | 1972-1981 | |
| 93 | Dutch H Leonard | 2.759 | 1913-1925 | |
| 94 | Sandy Koufax* | 2.761 | 1955-1966 | |
| 95 | Cy Falkenberg | 2.763 | 1903-1917 | |
| 96 | Jeff Pfeffer | 2.774 | 1911-1924 | |
| 97 | Al Demaree | 2.775 | 1912-1919 | |
| 98 | George Zettlein | 2.776 | 1871-1876 | |
| 99 | Jack Coombs | 2.781 | 1906-1920 | |
| 100 | Ed Karger | 2.787 | 1906-1911 |
