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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Robin Roberts* | 505 | 1948-1966 | |
| 2 | Jim Kaat | 441 | 1959-1979 | |
| 3 | Warren Spahn* | 434 | 1942-1965 | |
| 4 | Denny McLain# | 391 | 1963-1981 | |
| 5 | Fergie Jenkins# | 382 | 1965-1981 | |
| 6 | Don Sutton# | 367 | 1966-1981 | |
| 7 | Catfish Hunter# | 355 | 1965-1981 | |
| 8 | Jim Bunning | 354 | 1955-1973 | |
| 9 | Larry Dierker# | 351 | 1964-1981 | |
| 10 | Dave McNally# | 349 | 1962-1981 | |
| 11 | Early Wynn* | 338 | 1939-1963 | |
| 12 | Milt Pappas | 332 | 1957-1976 | |
| 13 | Mickey Lolich | 327 | 1963-1978 | |
| 14 | Bob Gibson | 323 | 1959-1979 | |
| 15 | Doug Rau# | 320 | 1970-1981 | |
| 16 | Murry Dickson | 302 | 1939-1959 | |
| 17 | Dick Drago# | 301 | 1969-1981 | |
| 18 | Phil Niekro# | 295 | 1964-1981 | |
| 19 | Ken Holtzman# | 293 | 1965-1981 | |
| 19 | Clay Kirby# | 293 | 1969-1981 | |
| 21 | Lew Burdette | 289 | 1950-1967 | |
| 21 | Bill Hands# | 289 | 1965-1981 | |
| 23 | Ray Sadecki | 288 | 1960-1979 | |
| 24 | Bob Friend | 286 | 1951-1966 | |
| 25 | Gary Nolan# | 284 | 1967-1981 | |
| 25 | Billy Pierce | 284 | 1945-1964 | |
| 27 | Jerry Koosman | 282 | 1967-1981 | |
| 28 | Gaylord Perry | 281 | 1962-1978 | |
| 29 | Don Drysdale* | 280 | 1956-1969 | |
| 30 | Jim Nash | 275 | 1966-1980 | |
| 31 | Bert Blyleven# | 274 | 1970-1981 | |
| 32 | Juan Marichal | 273 | 1960-1974 | |
| 33 | George H Stone# | 272 | 1967-1981 | |
| 34 | Jim Perry | 269 | 1959-1974 | |
| 35 | Vern Law | 268 | 1950-1967 | |
| 36 | Mike F McCormick | 262 | 1956-1974 | |
| 37 | Larry Jackson | 259 | 1955-1968 | |
| 38 | Rafael Jimenez# | 258 | 1971-1981 | |
| 39 | Jim Merritt | 257 | 1965-1977 | |
| 39 | Wallace Smallwood# | 257 | 1971-1981 | |
| 41 | Ray Culp | 256 | 1963-1979 | |
| 42 | Dick Bosman# | 255 | 1966-1981 | |
| 42 | Sam McDowell | 255 | 1961-1979 | |
| 42 | Curt Simmons | 255 | 1947-1967 | |
| 45 | Andy Messersmith# | 254 | 1968-1981 | |
| 45 | Red Ruffing* | 254 | 1924-1947 | |
| 47 | Don Newcombe | 252 | 1949-1960 | |
| 48 | Jim Palmer | 251 | 1965-1981 | |
| 49 | Bill Singer# | 250 | 1964-1981 | |
| 50 | Stan Bahnsen | 245 | 1966-1980 | |
| 51 | Johnny Podres | 242 | 1953-1969 | |
| 52 | Skip Lockwood# | 241 | 1969-1981 | |
| 53 | Harvey Haddix | 240 | 1952-1965 | |
| 54 | Mel Stottlemyre Sr# | 239 | 1964-1981 | |
| 55 | Bob Buhl | 238 | 1953-1967 | |
| 55 | Steve Busby# | 238 | 1970-1981 | |
| 57 | Joe H Coleman | 237 | 1965-1978 | |
| 57 | Tom Griffin# | 237 | 1969-1981 | |
| 59 | Earl Wilson | 236 | 1959-1970 | |
| 60 | Tommy John# | 232 | 1963-1981 | |
| 61 | Pat Jarvis | 229 | 1966-1979 | |
| 62 | Whitey Ford* | 228 | 1950-1967 | |
| 63 | Dick Donovan | 227 | 1949-1965 | |
| 63 | Carl Hubbell* | 227 | 1928-1943 | |
| 65 | Doug Bird# | 226 | 1970-1981 | |
| 65 | Tom Seaver | 226 | 1967-1979 | |
| 67 | Gary Peters | 225 | 1959-1975 | |
| 68 | Bob Feller* | 224 | 1936-1956 | |
| 69 | Ted Lyons* | 223 | 1923-1946 | |
| 70 | Don Cardwell | 222 | 1957-1971 | |
| 70 | Ed Halicki# | 222 | 1972-1981 | |
| 72 | Jim Hardin | 220 | 1967-1980 | |
| 73 | Steve Carlton# | 217 | 1965-1981 | |
| 73 | Joe Nuxhall | 217 | 1944-1966 | |
| 73 | Marty Pattin | 217 | 1968-1979 | |
| 76 | Ralph Terry | 216 | 1956-1967 | |
| 77 | Ned Garver | 213 | 1948-1961 | |
| 78 | Bill Monbouquette | 211 | 1958-1968 | |
| 79 | Herm Wehmeier | 210 | 1945-1958 | |
| 80 | Bobo Newsom | 206 | 1929-1953 | |
| 81 | Joe Horlen | 204 | 1961-1976 | |
| 81 | Sandy Koufax* | 204 | 1955-1966 | |
| 83 | Johnny Klippstein | 203 | 1950-1967 | |
| 84 | Steve Gromek | 201 | 1941-1957 | |
| 85 | Dick Ellsworth | 199 | 1958-1971 | |
| 85 | Carl Erskine | 199 | 1948-1959 | |
| 85 | Preacher Roe | 199 | 1938-1954 | |
| 88 | Frank Lary | 197 | 1954-1965 | |
| 88 | Larry Yount# | 197 | 1970-1980 | |
| 90 | Bob Purkey | 195 | 1954-1966 | |
| 91 | Jack Fisher | 193 | 1959-1969 | |
| 91 | Jim Maloney | 193 | 1960-1974 | |
| 93 | Juan Pizarro | 192 | 1957-1971 | |
| 93 | Ken Raffensberger | 192 | 1939-1954 | |
| 93 | Nolan Ryan# | 192 | 1966-1981 | |
| 93 | Earl Whitehill | 192 | 1923-1939 | |
| 97 | Larry Jansen | 191 | 1947-1956 | |
| 97 | Jon Matlack# | 191 | 1971-1981 | |
| 99 | Benjamin Ochoa# | 190 | 1974-1981 | |
| 100 | Bob Lemon | 189 | 1942-1958 |
