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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Bob Gibson | 11.67 | 1968 | |
| 2 | Sandy Koufax* | 11.50 | 1963 | |
| 3 | Sandy Koufax* | 10.88 | 1965 | |
| 4 | Bob Gibson | 10.33 | 1964 | |
| 5 | Ed Walsh* | 10.20 | 1906 | |
| 6 | Sonny Siebert | 10.19 | 1971 | |
| 7 | Nolan Ryan# | 10.02 | 1973 | |
| 8 | Jesse Barnes | 9.92 | 1921 | |
| 9 | Hal Newhouser | 9.58 | 1945 | |
| 10 | Marcos Ortega# | 9.56 | 1978 | |
| 11 | Vic Raschi | 9.53 | 1952 | |
| 12 | Marcos Ortega# | 9.50 | 1979 | |
| 13 | Whitey Ford* | 9.39 | 1958 | |
| 14 | Blake Green# | 9.14 | 1980 | |
| 15 | Mort Cooper | 9.00 | 1944 | |
| 15 | Mickey Lolich | 9.00 | 1971 | |
| 15 | Rudy May | 9.00 | 1973 | |
| 18 | Luke Walker | 8.83 | 1970 | |
| 19 | Bob Gibson | 8.67 | 1967 | |
| 20 | Nolan Ryan# | 8.64 | 1972 | |
| 21 | Smoky Joe Wood | 8.59 | 1912 | |
| 22 | Gary Nolan# | 8.50 | 1971 | |
| 23 | John Clarkson* | 8.44 | 1885 | |
| 23 | Sam McDowell | 8.44 | 1971 | |
| 25 | Steve Carlton# | 8.22 | 1978 | |
| 26 | John Clarkson* | 8.13 | 1886 | |
| 27 | Dave McNally# | 8.00 | 1969 | |
| 28 | Allie Reynolds | 7.97 | 1952 | |
| 29 | Bob Moose# | 7.94 | 1970 | |
| 29 | Sal Maglie | 7.94 | 1956 | |
| 31 | Bob Gibson | 7.80 | 1977 | |
| 32 | Tim Keefe* | 7.71 | 1888 | |
| 33 | Tom Seaver | 7.68 | 1972 | |
| 34 | Max Lanier | 7.63 | 1943 | |
| 35 | Pete Alexander* | 7.52 | 1926 | |
| 36 | Mike Cuellar | 7.50 | 1969 | |
| 36 | Denny Galehouse | 7.50 | 1944 | |
| 36 | Hod Eller | 7.50 | 1919 | |
| 36 | George Earnshaw | 7.50 | 1931 | |
| 36 | Walter Johnson* | 7.50 | 1924 | |
| 36 | Dick Rudolph | 7.50 | 1914 | |
| 42 | Orval Overall | 7.36 | 1908 | |
| 43 | Jack S Sanford | 7.33 | 1962 | |
| 43 | Sam McDowell | 7.33 | 1975 | |
| 45 | Tom Hall# | 7.31 | 1972 | |
| 46 | Joe H Coleman | 7.27 | 1975 | |
| 47 | Bill Dinneen | 7.20 | 1903 | |
| 47 | Tim Keefe* | 7.20 | 1884 | |
| 47 | Jack Coombs | 7.20 | 1911 | |
| 50 | Bob Turley | 7.16 | 1958 | |
| 51 | Steve Blass | 7.08 | 1970 | |
| 52 | Denny McLain# | 7.02 | 1968 | |
| 53 | Mickey Lolich | 7.00 | 1968 | |
| 53 | Whit Wyatt | 7.00 | 1941 | |
| 53 | Mordecai Brown* | 7.00 | 1910 | |
| 53 | Waite Hoyt* | 7.00 | 1928 | |
| 53 | Bert Blyleven# | 7.00 | 1978 | |
| 58 | Old Hoss Radbourn* | 6.95 | 1884 | |
| 59 | Charles Bender* | 6.92 | 1911 | |
| 60 | Charles Bender* | 6.88 | 1905 | |
| 60 | Burleigh Grimes* | 6.88 | 1930 | |
| 60 | Steve Busby# | 6.88 | 1981 | |
| 60 | Steve Carlton# | 6.88 | 1976 | |
| 64 | Clay Kirby# | 6.87 | 1975 | |
| 65 | Bill Donovan | 6.86 | 1907 | |
| 66 | George Earnshaw | 6.84 | 1930 | |
| 67 | Sam McDowell | 6.75 | 1977 | |
| 67 | Ray Culp | 6.75 | 1971 | |
| 67 | Ron Guidry# | 6.75 | 1979 | |
| 67 | Carl Hubbell* | 6.75 | 1933 | |
| 67 | Charles Bender* | 6.75 | 1910 | |
| 72 | Bob Veale | 6.60 | 1970 | |
| 72 | Pat Jarvis | 6.60 | 1972 | |
| 74 | Thomas Boyd# | 6.58 | 1976 | |
| 75 | Steve Shields# | 6.55 | 1980 | |
| 76 | Kid Nichols* | 6.50 | 1892 | |
| 76 | Rube Foster | 6.50 | 1915 | |
| 78 | Doug Rau# | 6.48 | 1975 | |
| 78 | Dave McNally# | 6.48 | 1970 | |
| 80 | Bob Moose# | 6.35 | 1981 | |
| 80 | Ed Crane | 6.35 | 1888 | |
| 82 | Tom M Carroll# | 6.26 | 1974 | |
| 83 | Tommy Bridges | 6.23 | 1934 | |
| 84 | Bob Gibson | 6.19 | 1974 | |
| 85 | Kenneth Kollmyer# | 6.15 | 1976 | |
| 86 | Silver King | 6.10 | 1887 | |
| 87 | Ed Halicki# | 6.06 | 1980 | |
| 88 | Waite Hoyt* | 6.00 | 1921 | |
| 88 | Christy Mathewson* | 6.00 | 1905 | |
| 88 | Gary Nolan# | 6.00 | 1973 | |
| 88 | Schoolboy Rowe | 6.00 | 1935 | |
| 88 | Waite Hoyt* | 6.00 | 1926 | |
| 93 | Jim Palmer | 5.97 | 1970 | |
| 94 | Dave McNally# | 5.93 | 1972 | |
| 95 | Dick Ruthven# | 5.91 | 1977 | |
| 95 | Gary Peters | 5.91 | 1971 | |
| 97 | Bill Hallahan | 5.89 | 1931 | |
| 98 | Phil Douglas | 5.88 | 1921 | |
| 98 | Dizzy Dean* | 5.88 | 1934 | |
| 98 | Bobo Newsom | 5.88 | 1940 |
