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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | TB | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Babe Ruth* | 457 | 1921 | |
| 2 | Rogers Hornsby* | 450 | 1922 | |
| 3 | Lou Gehrig* | 447 | 1927 | |
| 4 | Chuck Klein | 445 | 1930 | |
| 5 | Jimmie Foxx* | 438 | 1932 | |
| 6 | Stan Musial* | 429 | 1948 | |
| 7 | Hack Wilson | 423 | 1930 | |
| 8 | Chuck Klein | 420 | 1932 | |
| 9 | Lou Gehrig* | 419 | 1930 | |
| 10 | Joe DiMaggio* | 418 | 1937 | |
| 11 | Babe Ruth* | 417 | 1927 | |
| 12 | Babe Herman | 416 | 1930 | |
| 13 | Lou Gehrig* | 410 | 1931 | |
| 14 | Lou Gehrig* | 409 | 1934 | |
| 14 | Rogers Hornsby* | 409 | 1929 | |
| 16 | Joe Medwick* | 406 | 1937 | |
| 17 | Chuck Klein | 405 | 1929 | |
| 17 | Hal Trosky Sr | 405 | 1936 | |
| 19 | Lou Gehrig* | 403 | 1936 | |
| 19 | Harry Simpson | 403 | 1950 | |
| 19 | Jimmie Foxx* | 403 | 1933 | |
| 22 | Hank Aaron | 400 | 1959 | |
| 23 | Babe Ruth* | 399 | 1923 | |
| 23 | George Sisler* | 399 | 1920 | |
| 25 | Jimmie Foxx* | 398 | 1938 | |
| 26 | Hank Greenberg* | 397 | 1937 | |
| 27 | Al Simmons* | 392 | 1930 | |
| 27 | Bill Terry* | 392 | 1930 | |
| 27 | Al Simmons* | 392 | 1925 | |
| 30 | Babe Ruth* | 391 | 1924 | |
| 31 | Hank Greenberg* | 389 | 1935 | |
| 32 | Babe Ruth* | 388 | 1920 | |
| 33 | Earl Averill | 385 | 1936 | |
| 34 | Hank Greenberg* | 384 | 1940 | |
| 35 | Willie Mays* | 382 | 1955 | |
| 35 | Stan Musial* | 382 | 1949 | |
| 35 | Willie Mays* | 382 | 1962 | |
| 38 | Rogers Hornsby* | 381 | 1925 | |
| 39 | Frank Robinson | 380 | 1962 | |
| 39 | Hank Greenberg* | 380 | 1938 | |
| 39 | Babe Ruth* | 380 | 1928 | |
| 42 | Ernie Banks* | 379 | 1958 | |
| 42 | Babe Ruth* | 379 | 1930 | |
| 44 | Duke Snider* | 378 | 1954 | |
| 44 | Rogers Hornsby* | 378 | 1921 | |
| 46 | Willie Mays* | 377 | 1954 | |
| 47 | Mickey Mantle* | 376 | 1956 | |
| 48 | Hugh Duffy* | 374 | 1894 | |
| 48 | Tony Oliva | 374 | 1964 | |
| 48 | Babe Ruth* | 374 | 1931 | |
| 48 | Hal Trosky Sr | 374 | 1934 | |
| 52 | Bill Terry* | 373 | 1932 | |
| 52 | Rogers Hornsby* | 373 | 1924 | |
| 52 | Al Simmons* | 373 | 1929 | |
| 55 | Hank Aaron | 370 | 1963 | |
| 55 | Lou Gehrig* | 370 | 1932 | |
| 55 | Duke Snider* | 370 | 1953 | |
| 58 | Ripper Collins | 369 | 1934 | |
| 58 | Hank Aaron | 369 | 1957 | |
| 58 | Kiki Cuyler* | 369 | 1925 | |
| 58 | Jimmie Foxx* | 369 | 1936 | |
| 58 | Max E West | 369 | 1949 | |
| 63 | Ted Kluszewski | 368 | 1954 | |
| 63 | Johnny Mize* | 368 | 1940 | |
| 63 | Ted Williams* | 368 | 1949 | |
| 66 | Frank Robinson | 367 | 1966 | |
| 66 | Al Rosen | 367 | 1953 | |
| 66 | Tommy Holmes | 367 | 1945 | |
| 66 | Heinie Manush* | 367 | 1928 | |
| 66 | Al Simmons* | 367 | 1932 | |
| 66 | Ken Williams | 367 | 1922 | |
| 66 | Joe DiMaggio* | 367 | 1936 | |
| 66 | Ty Cobb* | 367 | 1911 | |
| 66 | Joe Medwick* | 367 | 1936 | |
| 75 | Hank Aaron | 366 | 1962 | |
| 75 | Roger Maris | 366 | 1961 | |
| 75 | Stan Musial* | 366 | 1946 | |
| 75 | Willie Mays* | 366 | 1957 | |
| 75 | Lou Gehrig* | 366 | 1937 | |
| 80 | Chuck Klein | 365 | 1933 | |
| 80 | Harry Heilmann* | 365 | 1921 | |
| 80 | Joe Medwick* | 365 | 1935 | |
| 80 | Babe Ruth* | 365 | 1926 | |
| 84 | Lou Gehrig* | 364 | 1928 | |
| 85 | Eddie Mathews* | 363 | 1953 | |
| 85 | Dale Alexander | 363 | 1929 | |
| 87 | Jim Bottomley | 362 | 1928 | |
| 88 | Stan Musial* | 361 | 1953 | |
| 88 | Ralph Kiner | 361 | 1947 | |
| 88 | Ralph Kiner | 361 | 1949 | |
| 88 | Earl Averill | 361 | 1931 | |
| 92 | Carl Yastrzemski | 360 | 1967 | |
| 92 | Johnny Mize* | 360 | 1947 | |
| 92 | Willie Mays* | 360 | 1965 | |
| 95 | Lou Gehrig* | 359 | 1933 | |
| 95 | Earl Averill | 359 | 1932 | |
| 95 | Stan Musial* | 359 | 1954 | |
| 98 | Jimmie Foxx* | 358 | 1930 | |
| 98 | Ted Kluszewski | 358 | 1955 | |
| 98 | Jim Bottomley | 358 | 1925 |
