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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | W | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Cy Young* | 511 | 1890-1911 | |
| 2 | Walter Johnson* | 417 | 1907-1927 | |
| 3 | Pete Alexander* | 373 | 1911-1930 | |
| 3 | Christy Mathewson* | 373 | 1900-1916 | |
| 5 | Pud Galvin* | 364 | 1875-1892 | |
| 6 | Warren Spahn* | 363 | 1942-1965 | |
| 7 | Kid Nichols* | 361 | 1890-1906 | |
| 8 | Tim Keefe* | 342 | 1880-1893 | |
| 9 | John Clarkson* | 328 | 1882-1894 | |
| 10 | Bob Gibson | 325 | 1959-1979 | |
| 10 | Jim Kaat | 325 | 1959-1979 | |
| 12 | Old Hoss Radbourn* | 309 | 1881-1891 | |
| 13 | Mickey Welch | 307 | 1880-1892 | |
| 14 | Eddie Plank* | 305 | 1901-1917 | |
| 15 | Lefty Grove* | 300 | 1925-1941 | |
| 15 | Dave McNally# | 300 | 1962-1981 | |
| 15 | Early Wynn* | 300 | 1939-1963 | |
| 18 | Bobby Mathews | 297 | 1871-1887 | |
| 19 | Fergie Jenkins# | 287 | 1965-1981 | |
| 20 | Robin Roberts* | 286 | 1948-1966 | |
| 21 | Tony Mullane | 284 | 1881-1894 | |
| 22 | Red Ruffing* | 273 | 1924-1947 | |
| 23 | Burleigh Grimes* | 270 | 1916-1934 | |
| 24 | Bob Feller* | 266 | 1936-1956 | |
| 24 | Eppa Rixey* | 266 | 1912-1933 | |
| 26 | Jim McCormick | 265 | 1878-1887 | |
| 27 | Gus Weyhing | 264 | 1887-1901 | |
| 28 | Gary Nolan# | 263 | 1967-1981 | |
| 29 | Catfish Hunter# | 261 | 1965-1981 | |
| 29 | Denny McLain# | 261 | 1963-1981 | |
| 31 | Ted Lyons* | 260 | 1923-1946 | |
| 32 | Red Faber* | 254 | 1914-1933 | |
| 33 | Carl Hubbell* | 253 | 1928-1943 | |
| 33 | Al Spalding* | 253 | 1871-1877 | |
| 35 | Tom Seaver | 249 | 1967-1979 | |
| 35 | Vic Willis | 249 | 1898-1910 | |
| 37 | Joe McGinnity* | 246 | 1899-1908 | |
| 38 | Jack J Powell | 245 | 1897-1912 | |
| 38 | Amos Rusie | 245 | 1889-1901 | |
| 40 | Sam McDowell | 243 | 1961-1979 | |
| 41 | Herb Pennock* | 240 | 1912-1934 | |
| 42 | Clark Griffith* | 237 | 1891-1914 | |
| 42 | Waite Hoyt* | 237 | 1918-1938 | |
| 42 | Tommy John# | 237 | 1963-1981 | |
| 45 | Whitey Ford* | 236 | 1950-1967 | |
| 46 | Juan Marichal | 235 | 1960-1974 | |
| 47 | Tommy Bond | 234 | 1874-1884 | |
| 48 | Charlie Buffinton | 233 | 1882-1892 | |
| 49 | Mickey Lolich | 230 | 1963-1978 | |
| 50 | Sad Sam Jones | 229 | 1914-1935 | |
| 50 | Will White | 229 | 1877-1886 | |
| 52 | Don Sutton# | 226 | 1966-1981 | |
| 53 | Gaylord Perry | 224 | 1962-1978 | |
| 54 | Jim Bunning | 223 | 1955-1973 | |
| 54 | Paul Derringer | 223 | 1931-1945 | |
| 54 | Mel Harder | 223 | 1928-1947 | |
| 57 | Hooks Dauss | 222 | 1912-1926 | |
| 58 | Clay Kirby# | 219 | 1969-1981 | |
| 59 | Bob Caruthers | 218 | 1884-1892 | |
| 59 | Earl Whitehill | 218 | 1923-1939 | |
| 61 | Freddie Fitzsimmons | 217 | 1925-1943 | |
| 61 | Ken Holtzman# | 217 | 1965-1981 | |
| 63 | Wilbur Cooper | 216 | 1912-1926 | |
| 63 | Andy Messersmith# | 216 | 1968-1981 | |
| 63 | Bob Moose# | 216 | 1967-1981 | |
| 66 | Stan Coveleski* | 215 | 1912-1928 | |
| 67 | George Mullin | 212 | 1902-1913 | |
| 67 | Jack Quinn | 212 | 1909-1933 | |
| 69 | Steve Carlton# | 211 | 1965-1981 | |
| 69 | Bobo Newsom | 211 | 1929-1953 | |
| 69 | Billy Pierce | 211 | 1945-1964 | |
| 72 | Larry Dierker# | 210 | 1964-1981 | |
| 72 | Jesse Haines | 210 | 1918-1937 | |
| 72 | Bob Lemon | 210 | 1942-1958 | |
| 72 | Milt Pappas | 210 | 1957-1976 | |
| 76 | Don Drysdale* | 209 | 1956-1969 | |
| 76 | Jim Palmer | 209 | 1965-1981 | |
| 78 | Charles Bender* | 208 | 1903-1925 | |
| 78 | Mordecai Brown* | 208 | 1903-1916 | |
| 78 | Eddie Cicotte | 208 | 1905-1920 | |
| 81 | Carl Mays | 207 | 1915-1929 | |
| 81 | Hal Newhouser | 207 | 1939-1955 | |
| 83 | Phil Niekro# | 205 | 1964-1981 | |
| 84 | Al Orth | 204 | 1895-1909 | |
| 85 | Lew Burdette | 203 | 1950-1967 | |
| 85 | Silver King | 203 | 1886-1897 | |
| 85 | Jim Nash | 203 | 1966-1980 | |
| 85 | Gary Peters | 203 | 1959-1975 | |
| 85 | Jack Stivetts | 203 | 1889-1899 | |
| 90 | Rube Marquard | 201 | 1908-1925 | |
| 90 | Charlie Root | 201 | 1923-1941 | |
| 92 | George Uhle | 200 | 1919-1936 | |
| 93 | Bill Hands# | 199 | 1965-1981 | |
| 94 | Jack Chesbro* | 198 | 1899-1909 | |
| 94 | Bucky Walters | 198 | 1934-1950 | |
| 96 | Larry French | 197 | 1929-1942 | |
| 96 | Bob Friend | 197 | 1951-1966 | |
| 96 | Jesse Tannehill | 197 | 1894-1911 | |
| 96 | Adonis Terry | 197 | 1884-1897 | |
| 96 | Dazzy Vance* | 197 | 1915-1935 |
