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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | L | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Cy Young* | 316 | 1890-1911 | |
| 2 | Pud Galvin* | 310 | 1875-1892 | |
| 3 | Walter Johnson* | 279 | 1907-1927 | |
| 4 | Jim Kaat | 271 | 1959-1979 | |
| 5 | Jack J Powell | 254 | 1897-1912 | |
| 6 | Eppa Rixey* | 251 | 1912-1933 | |
| 7 | Bobby Mathews | 248 | 1871-1887 | |
| 8 | Robin Roberts* | 245 | 1948-1966 | |
| 8 | Warren Spahn* | 245 | 1942-1965 | |
| 10 | Early Wynn* | 244 | 1939-1963 | |
| 11 | Gus Weyhing | 232 | 1887-1901 | |
| 12 | Bob Friend | 230 | 1951-1966 | |
| 12 | Ted Lyons* | 230 | 1923-1946 | |
| 14 | Tim Keefe* | 225 | 1880-1893 | |
| 14 | Red Ruffing* | 225 | 1924-1947 | |
| 14 | Mel Stottlemyre Sr# | 225 | 1964-1981 | |
| 17 | Bobo Newsom | 222 | 1929-1953 | |
| 18 | Tony Mullane | 220 | 1881-1894 | |
| 18 | Don Sutton# | 220 | 1966-1981 | |
| 20 | Sad Sam Jones | 217 | 1914-1935 | |
| 21 | Catfish Hunter# | 216 | 1965-1981 | |
| 22 | Bob Gibson | 215 | 1959-1979 | |
| 23 | Jim McCormick | 214 | 1878-1887 | |
| 24 | Red Faber* | 213 | 1914-1933 | |
| 25 | Paul Derringer | 212 | 1931-1945 | |
| 25 | Chick Fraser | 212 | 1896-1909 | |
| 25 | Burleigh Grimes* | 212 | 1916-1934 | |
| 28 | Mickey Welch | 210 | 1880-1892 | |
| 29 | Pete Alexander* | 208 | 1911-1930 | |
| 29 | Kid Nichols* | 208 | 1890-1906 | |
| 31 | Vic Willis | 205 | 1898-1910 | |
| 32 | Jim Whitney | 204 | 1881-1890 | |
| 33 | Milt Pappas | 201 | 1957-1976 | |
| 34 | Dick Drago# | 199 | 1969-1981 | |
| 35 | Tommy John# | 198 | 1963-1981 | |
| 36 | Clay Kirby# | 196 | 1969-1981 | |
| 36 | Dave McNally# | 196 | 1962-1981 | |
| 36 | Adonis Terry | 196 | 1884-1897 | |
| 39 | Old Hoss Radbourn* | 195 | 1881-1891 | |
| 40 | Gaylord Perry | 194 | 1962-1978 | |
| 41 | Tom Zachary | 191 | 1918-1936 | |
| 42 | Al Orth | 189 | 1895-1909 | |
| 43 | Christy Mathewson* | 188 | 1900-1916 | |
| 44 | Mel Harder | 186 | 1928-1947 | |
| 45 | Earl Whitehill | 185 | 1923-1939 | |
| 46 | George Mullin | 184 | 1902-1913 | |
| 47 | Bullet Joe Bush | 183 | 1912-1928 | |
| 47 | Larry Dierker# | 183 | 1964-1981 | |
| 47 | Larry Jackson | 183 | 1955-1968 | |
| 47 | Eddie Plank* | 183 | 1901-1917 | |
| 47 | Curt Simmons | 183 | 1947-1967 | |
| 52 | Hooks Dauss | 182 | 1912-1926 | |
| 52 | Ken Holtzman# | 182 | 1965-1981 | |
| 52 | Waite Hoyt* | 182 | 1918-1938 | |
| 52 | Jack Quinn | 182 | 1909-1933 | |
| 56 | Murry Dickson | 181 | 1939-1959 | |
| 56 | Dutch E Leonard | 181 | 1933-1953 | |
| 58 | Lee Meadows | 180 | 1915-1929 | |
| 59 | Pink Hawley | 179 | 1892-1901 | |
| 59 | Dolf Luque | 179 | 1914-1935 | |
| 61 | John Clarkson* | 178 | 1882-1894 | |
| 61 | Wilbur Cooper | 178 | 1912-1926 | |
| 61 | Andy Messersmith# | 178 | 1968-1981 | |
| 64 | Bill Dinneen | 177 | 1898-1909 | |
| 64 | Joe Horlen | 177 | 1961-1976 | |
| 64 | Rube Marquard | 177 | 1908-1925 | |
| 64 | Denny McLain# | 177 | 1963-1981 | |
| 68 | Fergie Jenkins# | 176 | 1965-1981 | |
| 69 | Red Donahue | 175 | 1893-1906 | |
| 69 | Tom J Hughes | 175 | 1900-1913 | |
| 71 | Sam McDowell | 174 | 1961-1979 | |
| 71 | Amos Rusie | 174 | 1889-1901 | |
| 71 | Bill Singer# | 174 | 1964-1981 | |
| 74 | Larry French | 171 | 1929-1942 | |
| 75 | Dick Bosman# | 170 | 1966-1981 | |
| 75 | Ted Breitenstein | 170 | 1891-1901 | |
| 75 | Mickey Lolich | 170 | 1963-1978 | |
| 78 | Billy Pierce | 169 | 1945-1964 | |
| 79 | Bill Hands# | 168 | 1965-1981 | |
| 80 | Red Ames | 167 | 1903-1919 | |
| 80 | Jim Bunning | 167 | 1955-1973 | |
| 80 | Bert Cunningham | 167 | 1887-1901 | |
| 80 | Red Ehret | 167 | 1888-1898 | |
| 84 | Don Drysdale* | 166 | 1956-1969 | |
| 84 | George Uhle | 166 | 1919-1936 | |
| 84 | Will White | 166 | 1877-1886 | |
| 87 | Mark Baldwin | 165 | 1887-1893 | |
| 87 | Bump Hadley | 165 | 1926-1941 | |
| 87 | Si Johnson | 165 | 1928-1947 | |
| 87 | Phil Niekro# | 165 | 1964-1981 | |
| 91 | Howard Ehmke | 164 | 1916-1930 | |
| 91 | Milt Gaston | 164 | 1924-1934 | |
| 91 | Win Mercer | 164 | 1894-1902 | |
| 91 | Jim Nash | 164 | 1966-1980 | |
| 91 | Don Wilson# | 164 | 1966-1981 | |
| 96 | Tommy Bond | 163 | 1874-1884 | |
| 96 | Bill Hutchinson | 163 | 1884-1897 | |
| 96 | Ray Sadecki | 163 | 1960-1979 | |
| 99 | Bob Feller* | 162 | 1936-1956 | |
| 99 | Herb Pennock* | 162 | 1912-1934 |
