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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Bob Gibson | 157.0 | 1959-1979 | |
| 2 | Bob Caruthers | 147.0 | 1884-1892 | |
| 3 | Whitey Ford* | 146.0 | 1950-1967 | |
| 4 | Tommy John# | 128.0 | 1963-1981 | |
| 5 | Gary Nolan# | 126.0 | 1967-1981 | |
| 6 | Dick Ruthven# | 124.0 | 1972-1981 | |
| 7 | Sam McDowell | 114.0 | 1961-1979 | |
| 8 | Dave McNally# | 102.0 | 1962-1981 | |
| 9 | Christy Mathewson* | 101.0 | 1900-1916 | |
| 10 | Tom Seaver | 91.0 | 1967-1979 | |
| 11 | Steve Carlton# | 87.0 | 1965-1981 | |
| 12 | Red Ruffing* | 85.0 | 1924-1947 | |
| 12 | Charles Bender* | 85.0 | 1903-1925 | |
| 14 | Waite Hoyt* | 83.0 | 1918-1938 | |
| 15 | Bob Moose# | 82.0 | 1967-1981 | |
| 16 | Art Nehf | 79.0 | 1915-1929 | |
| 17 | Allie Reynolds | 77.0 | 1942-1954 | |
| 18 | Dave Foutz | 75.0 | 1884-1896 | |
| 19 | Jim Palmer | 74.0 | 1965-1981 | |
| 20 | Ed Halicki# | 69.0 | 1972-1981 | |
| 21 | Burt Hooton | 68.0 | 1971-1978 | |
| 22 | Silver King | 66.0 | 1886-1897 | |
| 23 | John Clarkson* | 64.0 | 1882-1894 | |
| 24 | George Earnshaw | 62.0 | 1928-1936 | |
| 24 | Adonis Terry | 62.0 | 1884-1897 | |
| 26 | Tim Keefe* | 61.0 | 1880-1893 | |
| 26 | Cy Young* | 61.0 | 1890-1911 | |
| 28 | Bullet Joe Bush | 60.0 | 1912-1928 | |
| 28 | Mickey Lolich | 60.0 | 1963-1978 | |
| 28 | Vic Raschi | 60.0 | 1946-1955 | |
| 31 | Rube Marquard | 58.0 | 1908-1925 | |
| 31 | Pretzels Getzien | 58.0 | 1884-1892 | |
| 31 | George Mullin | 58.0 | 1902-1913 | |
| 34 | Mordecai Brown* | 57.0 | 1903-1916 | |
| 34 | Carl Mays | 57.0 | 1915-1929 | |
| 34 | Sandy Koufax* | 57.0 | 1955-1966 | |
| 37 | Burleigh Grimes* | 56.0 | 1916-1934 | |
| 37 | Warren Spahn* | 56.0 | 1942-1965 | |
| 39 | Herb Pennock* | 55.0 | 1912-1934 | |
| 39 | Ed Crane | 55.0 | 1884-1893 | |
| 41 | Eddie Plank* | 54.0 | 1901-1917 | |
| 41 | Frank Riccelli# | 54.0 | 1975-1981 | |
| 43 | Bob Turley | 53.0 | 1951-1963 | |
| 43 | Jack Coombs | 53.0 | 1906-1920 | |
| 45 | Paul Derringer | 52.0 | 1931-1945 | |
| 45 | Eddie Lopat | 52.0 | 1944-1955 | |
| 47 | Lefty Grove* | 51.0 | 1925-1941 | |
| 47 | Orval Overall | 51.0 | 1905-1913 | |
| 49 | Lefty Gomez | 50.0 | 1930-1943 | |
| 49 | Carl Hubbell* | 50.0 | 1928-1943 | |
| 49 | Bill Donovan | 50.0 | 1898-1918 | |
| 49 | Walter Johnson* | 50.0 | 1907-1927 | |
| 49 | Deacon Phillippe | 50.0 | 1899-1911 | |
| 54 | Lew Burdette | 49.0 | 1950-1967 | |
| 55 | Nolan Ryan# | 46.0 | 1966-1981 | |
| 55 | Tommy Bridges | 46.0 | 1930-1946 | |
| 55 | Clay Kirby# | 46.0 | 1969-1981 | |
| 55 | Schoolboy Rowe | 46.0 | 1933-1950 | |
| 55 | Ralph Terry | 46.0 | 1956-1967 | |
| 60 | Mort Cooper | 45.0 | 1938-1949 | |
| 61 | Eddie Cicotte | 44.0 | 1905-1920 | |
| 61 | Tom M Carroll# | 44.0 | 1974-1981 | |
| 61 | Ice Box Chamberlin | 44.0 | 1886-1896 | |
| 61 | Jim McCormick | 44.0 | 1878-1887 | |
| 65 | Tom Underwood# | 43.0 | 1974-1981 | |
| 65 | Pete Alexander* | 43.0 | 1911-1930 | |
| 67 | Kenneth Kollmyer# | 42.0 | 1974-1981 | |
| 67 | Lady Baldwin | 42.0 | 1884-1890 | |
| 69 | Carl Erskine | 41.0 | 1948-1959 | |
| 69 | Bob Shawkey | 41.0 | 1913-1927 | |
| 69 | Stan Coveleski* | 41.0 | 1912-1928 | |
| 69 | Marcos Ortega# | 41.0 | 1976-1981 | |
| 73 | Don Drysdale* | 39.0 | 1956-1969 | |
| 73 | Bill Hallahan | 39.0 | 1925-1938 | |
| 75 | Thomas Boyd# | 38.0 | 1975-1981 | |
| 75 | Denny McLain# | 38.0 | 1963-1981 | |
| 75 | Johnny Podres | 38.0 | 1953-1969 | |
| 75 | Steve Brown# | 38.0 | 1975-1981 | |
| 75 | Tom Lovett | 38.0 | 1885-1894 | |
| 80 | Ray Culp | 36.0 | 1963-1979 | |
| 80 | Rudy May | 36.0 | 1965-1976 | |
| 80 | Joe H Coleman | 36.0 | 1965-1978 | |
| 80 | Don Larsen | 36.0 | 1953-1967 | |
| 84 | Monte Pearson | 35.0 | 1932-1941 | |
| 84 | Bill Dinneen | 35.0 | 1898-1909 | |
| 86 | Ernie Shore | 34.0 | 1912-1920 | |
| 86 | Dizzy Dean* | 34.0 | 1930-1947 | |
| 86 | Jack Pfiester | 34.0 | 1903-1911 | |
| 89 | Jerry Reuss# | 33.0 | 1969-1981 | |
| 89 | Spud Chandler | 33.0 | 1937-1947 | |
| 89 | Pete Conway | 33.0 | 1885-1889 | |
| 89 | Lefty Tyler | 33.0 | 1910-1921 | |
| 93 | Harry Brecheen | 32.0 | 1940-1953 | |
| 93 | Ed Reulbach | 32.0 | 1905-1917 | |
| 93 | Hal Schumacher | 32.0 | 1931-1946 | |
| 93 | Jesse Haines | 32.0 | 1918-1937 | |
| 93 | Jeff Tesreau | 32.0 | 1912-1918 | |
| 93 | Willie Hernandez# | 32.0 | 1975-1981 | |
| 93 | Doug Rau# | 32.0 | 1970-1981 | |
| 100 | Mike Cuellar | 31.0 | 1959-1972 |
