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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Sandy Koufax* | 9.63 | 1955-1966 | |
| 2 | Nolan Ryan# | 9.45 | 1966-1981 | |
| 3 | Marcos Ortega# | 9.44 | 1976-1981 | |
| 4 | Bob Gibson | 8.77 | 1959-1979 | |
| 5 | Don Drysdale* | 8.17 | 1956-1969 | |
| 6 | George Earnshaw | 8.04 | 1928-1936 | |
| 7 | Mickey Lolich | 7.71 | 1963-1978 | |
| 7 | Bob Turley | 7.71 | 1951-1963 | |
| 9 | Mike Cuellar | 7.39 | 1959-1972 | |
| 10 | Sam McDowell | 7.38 | 1961-1979 | |
| 11 | John Clarkson* | 7.31 | 1882-1894 | |
| 12 | Allie Reynolds | 7.22 | 1942-1954 | |
| 13 | Bill Dinneen | 7.20 | 1898-1909 | |
| 14 | Max Lanier | 7.11 | 1938-1953 | |
| 15 | Bob Moose# | 7.08 | 1967-1981 | |
| 16 | Monte Pearson | 7.07 | 1932-1941 | |
| 17 | Mort Cooper | 7.00 | 1938-1949 | |
| 18 | Steve Carlton# | 6.90 | 1965-1981 | |
| 19 | Clay Kirby# | 6.85 | 1969-1981 | |
| 20 | Tim Keefe* | 6.79 | 1880-1893 | |
| 21 | Thomas Boyd# | 6.75 | 1975-1981 | |
| 21 | Tom M Carroll# | 6.75 | 1974-1981 | |
| 23 | Carl Erskine | 6.70 | 1948-1959 | |
| 24 | Rudy May | 6.69 | 1965-1976 | |
| 25 | Joe H Coleman | 6.50 | 1965-1978 | |
| 26 | Dave McNally# | 6.44 | 1962-1981 | |
| 27 | Vic Raschi | 6.41 | 1946-1955 | |
| 27 | Red Ruffing* | 6.41 | 1924-1947 | |
| 29 | Lefty Grove* | 6.31 | 1925-1941 | |
| 30 | Walter Johnson* | 6.30 | 1907-1927 | |
| 31 | Charles Bender* | 6.25 | 1903-1925 | |
| 32 | Orval Overall | 6.14 | 1905-1913 | |
| 33 | Bill Hallahan | 6.13 | 1925-1938 | |
| 34 | Pete Alexander* | 6.07 | 1911-1930 | |
| 34 | Ralph Terry | 6.07 | 1956-1967 | |
| 36 | Don Larsen | 6.00 | 1953-1967 | |
| 37 | Bill Donovan | 5.94 | 1898-1918 | |
| 38 | Doug Rau# | 5.91 | 1970-1981 | |
| 39 | Ray Culp | 5.89 | 1963-1979 | |
| 40 | Whitey Ford* | 5.79 | 1950-1967 | |
| 41 | Kenneth Kollmyer# | 5.74 | 1974-1981 | |
| 41 | Jack Coombs | 5.74 | 1906-1920 | |
| 43 | Carl Hubbell* | 5.72 | 1928-1943 | |
| 44 | Tom Seaver | 5.60 | 1967-1979 | |
| 45 | George Mullin | 5.59 | 1902-1913 | |
| 46 | Jeff Tesreau | 5.57 | 1912-1918 | |
| 47 | Gary Nolan# | 5.56 | 1967-1981 | |
| 48 | Lefty Gomez | 5.54 | 1930-1943 | |
| 49 | Mordecai Brown* | 5.46 | 1903-1916 | |
| 50 | Rube Marquard | 5.37 | 1908-1925 | |
| 51 | Tommy Bridges | 5.28 | 1930-1946 | |
| 51 | Schoolboy Rowe | 5.28 | 1933-1950 | |
| 53 | Waite Hoyt* | 5.27 | 1918-1938 | |
| 53 | Eddie Plank* | 5.27 | 1901-1917 | |
| 55 | Dick Ruthven# | 5.15 | 1972-1981 | |
| 56 | Warren Spahn* | 5.14 | 1942-1965 | |
| 57 | Paul Derringer | 5.13 | 1931-1945 | |
| 58 | Ed Crane | 5.07 | 1884-1893 | |
| 59 | Jim Palmer | 5.06 | 1965-1981 | |
| 60 | Ed Halicki# | 5.04 | 1972-1981 | |
| 61 | Dizzy Dean* | 4.98 | 1930-1947 | |
| 62 | Harry Brecheen | 4.96 | 1940-1953 | |
| 63 | Denny McLain# | 4.89 | 1963-1981 | |
| 64 | Steve Brown# | 4.74 | 1975-1981 | |
| 65 | Jim McCormick | 4.70 | 1878-1887 | |
| 66 | Hal Schumacher | 4.68 | 1931-1946 | |
| 67 | Lew Burdette | 4.56 | 1950-1967 | |
| 68 | Willie Hernandez# | 4.50 | 1975-1981 | |
| 68 | Silver King | 4.50 | 1886-1897 | |
| 70 | Frank Riccelli# | 4.47 | 1975-1981 | |
| 71 | Burleigh Grimes* | 4.45 | 1916-1934 | |
| 72 | Johnny Sain | 4.40 | 1942-1955 | |
| 73 | Deacon Phillippe | 4.32 | 1899-1911 | |
| 73 | Spud Chandler | 4.32 | 1937-1947 | |
| 75 | Clem Labine | 4.31 | 1950-1962 | |
| 76 | Christy Mathewson* | 4.25 | 1900-1916 | |
| 77 | Jack Pfiester | 4.24 | 1903-1911 | |
| 78 | Johnny Podres | 4.23 | 1953-1969 | |
| 79 | Eddie Cicotte | 4.03 | 1905-1920 | |
| 80 | Tom Underwood# | 3.92 | 1974-1981 | |
| 81 | Herb Pennock* | 3.90 | 1912-1934 | |
| 82 | Ernie Shore | 3.89 | 1912-1920 | |
| 82 | Bob Shawkey | 3.89 | 1913-1927 | |
| 84 | Tommy John# | 3.87 | 1963-1981 | |
| 85 | Cy Young* | 3.84 | 1890-1911 | |
| 86 | Jerry Reuss# | 3.74 | 1969-1981 | |
| 87 | Ed Reulbach | 3.58 | 1905-1917 | |
| 88 | Tom Lovett | 3.55 | 1885-1894 | |
| 89 | Dave Foutz | 3.48 | 1884-1896 | |
| 90 | Jesse Haines | 3.34 | 1918-1937 | |
| 91 | Burt Hooton | 3.31 | 1971-1978 | |
| 92 | Eddie Lopat | 3.29 | 1944-1955 | |
| 93 | Bob Caruthers | 3.24 | 1884-1892 | |
| 94 | Adonis Terry | 3.19 | 1884-1897 | |
| 94 | Art Nehf | 3.19 | 1915-1929 | |
| 96 | Pete Conway | 2.73 | 1885-1889 | |
| 97 | Bullet Joe Bush | 2.67 | 1912-1928 | |
| 97 | Carl Mays | 2.67 | 1915-1929 | |
| 99 | Ice Box Chamberlin | 2.66 | 1886-1896 | |
| 100 | Pretzels Getzien | 2.64 | 1884-1892 |
