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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Sam McDowell | 4009 | 1961-1979 | |
| 2 | Bob Gibson | 3921 | 1959-1979 | |
| 3 | Walter Johnson* | 3509 | 1907-1927 | |
| 4 | Fergie Jenkins# | 3233 | 1965-1981 | |
| 5 | Mickey Lolich | 2991 | 1963-1978 | |
| 6 | Nolan Ryan# | 2973 | 1966-1981 | |
| 7 | Jim Kaat | 2919 | 1959-1979 | |
| 8 | Don Sutton# | 2884 | 1966-1981 | |
| 9 | Dave McNally# | 2804 | 1962-1981 | |
| 10 | Cy Young* | 2803 | 1890-1911 | |
| 11 | Jim Bunning | 2749 | 1955-1973 | |
| 12 | Clay Kirby# | 2680 | 1969-1981 | |
| 13 | Gary Nolan# | 2638 | 1967-1981 | |
| 14 | Warren Spahn* | 2583 | 1942-1965 | |
| 15 | Bob Feller* | 2581 | 1936-1956 | |
| 16 | Gaylord Perry | 2571 | 1962-1978 | |
| 17 | Tim Keefe* | 2562 | 1880-1893 | |
| 18 | Tom Seaver | 2514 | 1967-1979 | |
| 19 | Catfish Hunter# | 2508 | 1965-1981 | |
| 20 | Christy Mathewson* | 2502 | 1900-1916 | |
| 21 | Denny McLain# | 2493 | 1963-1981 | |
| 22 | Don Drysdale* | 2486 | 1956-1969 | |
| 23 | Larry Dierker# | 2471 | 1964-1981 | |
| 24 | Andy Messersmith# | 2458 | 1968-1981 | |
| 25 | Bill Singer# | 2409 | 1964-1981 | |
| 26 | Sandy Koufax* | 2396 | 1955-1966 | |
| 27 | Tommy John# | 2360 | 1963-1981 | |
| 28 | Robin Roberts* | 2357 | 1948-1966 | |
| 29 | Early Wynn* | 2334 | 1939-1963 | |
| 30 | Rube Waddell* | 2316 | 1897-1910 | |
| 31 | Steve Carlton# | 2284 | 1965-1981 | |
| 32 | Juan Marichal | 2268 | 1960-1974 | |
| 33 | Lefty Grove* | 2266 | 1925-1941 | |
| 34 | Phil Niekro# | 2214 | 1964-1981 | |
| 35 | Gary Peters | 2210 | 1959-1975 | |
| 36 | Pete Alexander* | 2198 | 1911-1930 | |
| 37 | Steve Busby# | 2194 | 1970-1981 | |
| 38 | Ken Holtzman# | 2193 | 1965-1981 | |
| 39 | Ray Culp | 2183 | 1963-1979 | |
| 40 | Jim Nash | 2165 | 1966-1980 | |
| 41 | Eddie Plank* | 2099 | 1901-1917 | |
| 42 | Doug Rau# | 2088 | 1970-1981 | |
| 43 | Bob Moose# | 2083 | 1967-1981 | |
| 44 | Bobo Newsom | 2082 | 1929-1953 | |
| 45 | Dazzy Vance* | 2045 | 1915-1935 | |
| 46 | Jim Palmer | 2032 | 1965-1981 | |
| 47 | Billy Pierce | 1999 | 1945-1964 | |
| 48 | Red Ruffing* | 1987 | 1924-1947 | |
| 49 | Ray Sadecki | 1982 | 1960-1979 | |
| 50 | John Clarkson* | 1978 | 1882-1894 | |
| 51 | Whitey Ford* | 1956 | 1950-1967 | |
| 52 | Amos Rusie | 1934 | 1889-1901 | |
| 53 | Bob Veale | 1924 | 1962-1974 | |
| 54 | Milt Pappas | 1923 | 1957-1976 | |
| 55 | Joe H Coleman | 1883 | 1965-1978 | |
| 56 | Kid Nichols* | 1868 | 1890-1906 | |
| 57 | Bert Blyleven# | 1865 | 1970-1981 | |
| 58 | Bill Hands# | 1861 | 1965-1981 | |
| 59 | Dean Chance | 1854 | 1961-1976 | |
| 59 | Jim Maloney | 1854 | 1960-1974 | |
| 61 | Mickey Welch | 1850 | 1880-1892 | |
| 62 | Jerry Koosman | 1839 | 1967-1981 | |
| 63 | Old Hoss Radbourn* | 1830 | 1881-1891 | |
| 64 | Pud Galvin* | 1806 | 1875-1892 | |
| 65 | Tony Mullane | 1803 | 1881-1894 | |
| 66 | Hal Newhouser | 1796 | 1939-1955 | |
| 67 | Luke Walker | 1772 | 1965-1981 | |
| 68 | Skip Lockwood# | 1737 | 1969-1981 | |
| 69 | Ed Walsh* | 1736 | 1904-1917 | |
| 70 | Bob Friend | 1734 | 1951-1966 | |
| 71 | Rick Rhoden# | 1712 | 1972-1981 | |
| 72 | Larry Jackson | 1709 | 1955-1968 | |
| 73 | Jim McCormick | 1704 | 1878-1887 | |
| 74 | Red Ames | 1702 | 1903-1919 | |
| 75 | Charlie Buffinton | 1700 | 1882-1892 | |
| 75 | Rafael Jimenez# | 1700 | 1971-1981 | |
| 77 | Curt Simmons | 1697 | 1947-1967 | |
| 78 | Mel Stottlemyre Sr# | 1691 | 1964-1981 | |
| 79 | Carl Hubbell* | 1677 | 1928-1943 | |
| 80 | Tommy Bridges | 1674 | 1930-1946 | |
| 81 | Gus Weyhing | 1665 | 1887-1901 | |
| 82 | Marcos Ortega# | 1660 | 1976-1981 | |
| 83 | Tom Griffin# | 1658 | 1969-1981 | |
| 83 | Chris Short | 1658 | 1959-1974 | |
| 85 | Bob D Johnson | 1656 | 1969-1978 | |
| 86 | Jim Merritt | 1655 | 1965-1977 | |
| 87 | Vic Willis | 1651 | 1898-1910 | |
| 87 | Don Wilson# | 1651 | 1966-1981 | |
| 89 | Dick Drago# | 1632 | 1969-1981 | |
| 90 | Ed Halicki# | 1623 | 1972-1981 | |
| 91 | Charles Bender* | 1622 | 1903-1925 | |
| 91 | Sam Jones | 1622 | 1951-1964 | |
| 93 | Jack J Powell | 1621 | 1897-1912 | |
| 94 | Rudy May | 1603 | 1965-1976 | |
| 95 | Rube Marquard | 1593 | 1908-1925 | |
| 96 | Harvey Haddix | 1575 | 1952-1965 | |
| 97 | Jim Whitney | 1571 | 1881-1890 | |
| 98 | Adonis Terry | 1553 | 1884-1897 | |
| 99 | Bill Donovan | 1552 | 1898-1918 | |
| 100 | Jim Perry | 1544 | 1959-1974 |
