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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Matt Kilroy | 513 | 1886 | |
| 2 | Toad Ramsey | 499 | 1886 | |
| 3 | Hugh Daily | 483 | 1884 | |
| 4 | Dupee Shaw | 451 | 1884 | |
| 5 | Old Hoss Radbourn* | 441 | 1884 | |
| 6 | Charlie Buffinton | 417 | 1884 | |
| 7 | Guy Hecker | 385 | 1884 | |
| 8 | Sandy Koufax* | 382 | 1965 | |
| 9 | Bill J Sweeney | 374 | 1884 | |
| 10 | Pud Galvin* | 369 | 1884 | |
| 11 | Mark Baldwin | 368 | 1889 | |
| 12 | Tim Keefe* | 361 | 1883 | |
| 13 | Toad Ramsey | 355 | 1887 | |
| 14 | Rube Waddell* | 349 | 1904 | |
| 14 | Rudy May | 349 | 1972 | |
| 16 | Bob Feller* | 348 | 1946 | |
| 17 | Hardie Henderson | 346 | 1884 | |
| 18 | Mickey Welch | 345 | 1884 | |
| 18 | Jim Whitney | 345 | 1883 | |
| 20 | Jim McCormick | 343 | 1884 | |
| 21 | Amos Rusie | 341 | 1890 | |
| 22 | Amos Rusie | 337 | 1891 | |
| 22 | Charlie Sweeney | 337 | 1884 | |
| 24 | Sam McDowell | 336 | 1970 | |
| 25 | Tim Keefe* | 335 | 1888 | |
| 26 | Tim Keefe* | 334 | 1884 | |
| 27 | Ed Morris | 326 | 1886 | |
| 28 | Sam McDowell | 325 | 1965 | |
| 28 | Tony Mullane | 325 | 1884 | |
| 30 | Lady Baldwin | 323 | 1886 | |
| 31 | Sandy Koufax* | 317 | 1966 | |
| 32 | Old Hoss Radbourn* | 315 | 1883 | |
| 33 | Bill Hutchinson | 314 | 1892 | |
| 34 | Walter Johnson* | 313 | 1910 | |
| 34 | John Clarkson* | 313 | 1886 | |
| 36 | Larry McKeon | 308 | 1884 | |
| 36 | John Clarkson* | 308 | 1885 | |
| 38 | Sandy Koufax* | 306 | 1963 | |
| 39 | Walter Johnson* | 303 | 1912 | |
| 40 | Ed Morris | 302 | 1884 | |
| 40 | Edwin Ramirez# | 302 | 1980 | |
| 40 | Rube Waddell* | 302 | 1903 | |
| 43 | Ed Morris | 298 | 1885 | |
| 44 | Sam McDowell | 297 | 1974 | |
| 44 | Tim Keefe* | 297 | 1886 | |
| 44 | Victor Sanchez# | 297 | 1977 | |
| 47 | Burt Hooton | 296 | 1972 | |
| 47 | Marcos Ortega# | 296 | 1980 | |
| 47 | Tom Seaver | 296 | 1971 | |
| 50 | Jack Lynch | 292 | 1884 | |
| 51 | Sadie McMahon | 291 | 1890 | |
| 52 | Bill Hutchinson | 289 | 1890 | |
| 52 | Jack Stivetts | 289 | 1890 | |
| 52 | Vida Blue | 289 | 1970 | |
| 55 | Amos Rusie | 288 | 1892 | |
| 56 | Rube Waddell* | 287 | 1905 | |
| 57 | Bobby Mathews | 286 | 1884 | |
| 57 | Mickey Lolich | 286 | 1970 | |
| 57 | Bobby Mathews | 286 | 1885 | |
| 60 | Rudy May | 285 | 1971 | |
| 60 | Marcos Ortega# | 285 | 1981 | |
| 60 | Marcos Ortega# | 285 | 1978 | |
| 60 | Victor Sanchez# | 285 | 1976 | |
| 64 | John Clarkson* | 284 | 1889 | |
| 64 | Billy Henry Taylor | 284 | 1884 | |
| 66 | Sam McDowell | 283 | 1968 | |
| 66 | Victor Sanchez# | 283 | 1978 | |
| 66 | Dave Foutz | 283 | 1886 | |
| 69 | Marcos Ortega# | 280 | 1977 | |
| 69 | Denny McLain# | 280 | 1968 | |
| 71 | Sam McDowell | 279 | 1969 | |
| 71 | Sam McDowell | 279 | 1975 | |
| 71 | Pud Galvin* | 279 | 1883 | |
| 71 | Sam McDowell | 279 | 1972 | |
| 75 | Bob Veale | 276 | 1965 | |
| 75 | Victor Rose# | 276 | 1977 | |
| 77 | Tom M Carroll# | 275 | 1975 | |
| 77 | Hal Newhouser | 275 | 1946 | |
| 79 | Burt Hooton | 274 | 1973 | |
| 80 | Fergie Jenkins# | 273 | 1969 | |
| 80 | Tom M Carroll# | 273 | 1977 | |
| 80 | Nolan Ryan# | 273 | 1977 | |
| 83 | Ed Seward | 272 | 1888 | |
| 83 | Larry Corcoran | 272 | 1884 | |
| 83 | Mickey Welch | 272 | 1886 | |
| 86 | Mickey Lolich | 271 | 1969 | |
| 86 | Steve Shields# | 271 | 1981 | |
| 88 | Bob Gibson | 270 | 1965 | |
| 88 | Jim Whitney | 270 | 1884 | |
| 90 | Sandy Koufax* | 269 | 1961 | |
| 90 | Bob Gibson | 269 | 1969 | |
| 90 | Andy Messersmith# | 269 | 1971 | |
| 90 | Ed Walsh* | 269 | 1908 | |
| 94 | Larry Corcoran | 268 | 1880 | |
| 94 | Bob Gibson | 268 | 1968 | |
| 94 | Bill Wise | 268 | 1884 | |
| 94 | Jim Bunning | 268 | 1965 | |
| 98 | Nolan Ryan# | 267 | 1975 | |
| 98 | Christy Mathewson* | 267 | 1903 | |
| 98 | Bob Gibson | 267 | 1970 |
